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2rvj
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2rvj is ON HOLD Authors: Yang, Y., Allemand, F., Guichou, J., Labesse, G. Description: pET22-hESRP1-RRM3 Category: Unreleased Structures [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of Epithelial splicing regulatory protein 1== | |
| - | + | <StructureSection load='2rvj' size='340' side='right'caption='[[2rvj]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2rvj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RVJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rvj OCA], [https://pdbe.org/2rvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rvj RCSB], [https://www.ebi.ac.uk/pdbsum/2rvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rvj ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Allemand | + | [https://www.uniprot.org/uniprot/ESRP1_HUMAN ESRP1_HUMAN] mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. |
| - | [[Category: Labesse | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allemand F]] | ||
| + | [[Category: Guichou J]] | ||
| + | [[Category: Labesse G]] | ||
| + | [[Category: Yang Y]] | ||
Current revision
NMR structure of Epithelial splicing regulatory protein 1
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