4txk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Construct of MICAL-1 containing the monooxygenase and calponin homology domains== | |
| - | + | <StructureSection load='4txk' size='340' side='right'caption='[[4txk]], [[Resolution|resolution]] 2.88Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4txk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.878Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txk OCA], [https://pdbe.org/4txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txk RCSB], [https://www.ebi.ac.uk/pdbsum/4txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txk ProSAT]</span></td></tr> |
| - | [[Category: Alqassim | + | </table> |
| - | [[Category: Amzel | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MICA1_MOUSE MICA1_MOUSE] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments (By similarity). Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Alqassim SS]] | ||
| + | [[Category: Amzel LM]] | ||
| + | [[Category: Bianchet MA]] | ||
Current revision
Construct of MICAL-1 containing the monooxygenase and calponin homology domains
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