4v0s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative== | |
| + | <StructureSection load='4v0s' size='340' side='right'caption='[[4v0s]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4v0s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V0S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HN:(1R,2S,4S,5R)-2-(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL-1,4,5-TRIHYDROXY-3-OXOCYCLOHEXANE-1-CARBOXYLIC+ACID'>2HN</scene>, <scene name='pdbligand=7HN:3,4-DIHYDROXY-2-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]BENZOIC+ACID'>7HN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0s OCA], [https://pdbe.org/4v0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v0s RCSB], [https://www.ebi.ac.uk/pdbsum/4v0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v0s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | ||
| - | + | ==See Also== | |
| - | + | *[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Hawkins | + | [[Category: Mycobacterium tuberculosis]] |
| - | [[Category: Lamb | + | [[Category: Gonzalez-Bello C]] |
| - | [[Category: | + | [[Category: Hawkins AR]] |
| - | [[Category: Maneiro | + | [[Category: Lamb H]] |
| - | [[Category: | + | [[Category: Llamas-Saiz AL]] |
| - | [[Category: | + | [[Category: Maneiro M]] |
| - | [[Category: | + | [[Category: Otero JM]] |
| - | [[Category: | + | [[Category: Peon A]] |
| + | [[Category: Santiago C]] | ||
| + | [[Category: Van Raaij MJ]] | ||
Current revision
Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative
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