We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

4yy7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (03:44, 21 November 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4yy7 is ON HOLD until Paper Publication
+
==The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with avian receptor analog 3'SLNLN==
 +
<StructureSection load='4yy7' size='340' side='right'caption='[[4yy7]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4yy7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/H6N1_subtype H6N1 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YY7 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yy7 OCA], [https://pdbe.org/4yy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yy7 RCSB], [https://www.ebi.ac.uk/pdbsum/4yy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yy7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/A0A0J9X268_9INFA A0A0J9X268_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[SAAS:SAAS00842036] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
-
Authors: Wang, F., Qi, J., Bi, Y., Zhang, W., Wang, M., Wang, M., Liu, J., Yan, J., Shi, Y., Gao, G.F.
+
==See Also==
-
 
+
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
-
Description: The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with avian receptor analog 3'SLNLN
+
__TOC__
-
[[Category: Unreleased Structures]]
+
</StructureSection>
-
[[Category: Wang, M]]
+
[[Category: H6N1 subtype]]
-
[[Category: Gao, G.F]]
+
[[Category: Large Structures]]
-
[[Category: Zhang, W]]
+
[[Category: Bi Y]]
-
[[Category: Wang, F]]
+
[[Category: Gao GF]]
-
[[Category: Yan, J]]
+
[[Category: Liu J]]
-
[[Category: Liu, J]]
+
[[Category: Qi J]]
-
[[Category: Shi, Y]]
+
[[Category: Shi Y]]
-
[[Category: Bi, Y]]
+
[[Category: Wang F]]
-
[[Category: Qi, J]]
+
[[Category: Wang M]]
 +
[[Category: Yan J]]
 +
[[Category: Zhang W]]

Current revision

The structure of hemagglutinin from a H6N1 influenza virus (A/chicken/Taiwan/A2837/2013) in complex with avian receptor analog 3'SLNLN

PDB ID 4yy7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4yy7"
Personal tools