4zeg

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'''Unreleased structure'''
 
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The entry 4zeg is ON HOLD until Apr 20 2017
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==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor==
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<StructureSection load='4zeg' size='340' side='right'caption='[[4zeg]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [https://pdbe.org/4zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [https://www.ebi.ac.uk/pdbsum/4zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zeg ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
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Authors: Qiu, W., Plotnikova, O., Feher, M., Awrey, D.E., Battaile, K., Chirgadze, N.Y.
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==See Also==
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*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
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Description: Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Battaile, K]]
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__TOC__
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[[Category: Feher, M]]
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</StructureSection>
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[[Category: Chirgadze, N.Y]]
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[[Category: Homo sapiens]]
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[[Category: Awrey, D.E]]
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[[Category: Large Structures]]
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[[Category: Qiu, W]]
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[[Category: Awrey DE]]
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[[Category: Plotnikova, O]]
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[[Category: Battaile K]]
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[[Category: Chirgadze NY]]
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[[Category: Feher M]]
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[[Category: Plotnikova O]]
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[[Category: Qiu W]]

Current revision

Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor

PDB ID 4zeg

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