4zxb

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'''Unreleased structure'''
 
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The entry 4zxb is ON HOLD
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==Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules==
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<StructureSection load='4zxb' size='340' side='right'caption='[[4zxb]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zxb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2dtg 2dtg] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3loh 3loh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZXB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxb OCA], [https://pdbe.org/4zxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zxb RCSB], [https://www.ebi.ac.uk/pdbsum/4zxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/U5LP42_MOUSE U5LP42_MOUSE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Insulin receptor (IR) signaling is critical to controlling nutrient uptake and metabolism. However, only a low-resolution (3.8 A) structure currently exists for the IR ectodomain, with some segments ill-defined or unmodeled due to disorder. Here, we revise this structure using new diffraction data to 3.3 A resolution that allow improved modeling of the N-linked glycans, the first and third fibronectin type III domains, and the insert domain. A novel haptic interactive molecular dynamics strategy was used to aid fitting to low-resolution electron density maps. The resulting model provides a foundation for investigation of structural transitions in IR upon ligand binding.
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Authors: Croll, T., Smith, B.J., Margetts, M.B., Whittaker, J., Weiss, M.A., Ward, C.W., Lawrence, M.C.
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Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.,Croll TI, Smith BJ, Margetts MB, Whittaker J, Weiss MA, Ward CW, Lawrence MC Structure. 2016 Jan 27. pii: S0969-2126(16)00007-1. doi:, 10.1016/j.str.2015.12.014. PMID:26853939<ref>PMID:26853939</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Whittaker, J]]
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<div class="pdbe-citations 4zxb" style="background-color:#fffaf0;"></div>
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[[Category: Margetts, M.B]]
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[[Category: Lawrence, M.C]]
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==See Also==
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[[Category: Weiss, M.A]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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[[Category: Ward, C.W]]
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*[[Insulin receptor 3D structures|Insulin receptor 3D structures]]
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[[Category: Croll, T]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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[[Category: Smith, B.J]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Croll T]]
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[[Category: Lawrence MC]]
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[[Category: Margetts MB]]
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[[Category: Smith BJ]]
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[[Category: Ward CW]]
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[[Category: Weiss MA]]
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[[Category: Whittaker J]]

Current revision

Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules

PDB ID 4zxb

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