5a1n

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'''Unreleased structure'''
 
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The entry 5a1n is ON HOLD until May 03 2017
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==The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D==
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<StructureSection load='5a1n' size='340' side='right'caption='[[5a1n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5a1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1n OCA], [https://pdbe.org/5a1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1n RCSB], [https://www.ebi.ac.uk/pdbsum/5a1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYEP_HUMAN SYEP_HUMAN] Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.<ref>PMID:1756734</ref> <ref>PMID:15479637</ref> <ref>PMID:23071094</ref>
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Authors: Cho, H.Y., Choi, Y.S., Kang, B.S.
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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Description: The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Cho, H.Y]]
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__TOC__
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[[Category: Kang, B.S]]
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</StructureSection>
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[[Category: Choi, Y.S]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cho HY]]
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[[Category: Choi YS]]
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[[Category: Kang BS]]

Current revision

The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D

PDB ID 5a1n

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