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190d

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[[Image:190d.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a four-stranded intercalated DNA: d(C4)==
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|PDB= 190d |SIZE=350|CAPTION= <scene name='initialview01'>190d</scene>, resolution 1.800&Aring;
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<StructureSection load='190d' size='340' side='right'caption='[[190d]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>
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<table><tr><td colspan='2'>[[190d]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=190D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [https://pdbe.org/190d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=190d RCSB], [https://www.ebi.ac.uk/pdbsum/190d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=190d ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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__TOC__
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=190d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=190d OCA], [http://www.ebi.ac.uk/pdbsum/190d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=190d RCSB]</span>
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</StructureSection>
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}}
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[[Category: Large Structures]]
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[[Category: Cai L]]
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'''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''
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[[Category: Chen L]]
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[[Category: Rich A]]
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[[Category: Zhang X]]
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==Overview==
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The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
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==About this Structure==
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190D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].
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==Reference==
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Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7947764 7947764]
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[[Category: Protein complex]]
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[[Category: Cai, L.]]
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[[Category: Chen, L.]]
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[[Category: Rich, A.]]
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[[Category: Zhang, X.]]
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[[Category: base intercalated]]
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[[Category: mismatched]]
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[[Category: parallel-stranded tetraplex]]
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[[Category: quadruple helix]]
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[[Category: u-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:29:47 2008''
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Current revision

Crystal structure of a four-stranded intercalated DNA: d(C4)

PDB ID 190d

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