5enn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5enn is ON HOLD Authors: Kearney, E.P. Description: The crystal structure of Human VPS34 in complex with a selective and potent inhibitor [[Categor...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of Human VPS34 in complex with a selective and potent inhibitor== |
| + | <StructureSection load='5enn' size='340' side='right'caption='[[5enn]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5enn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ENN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5QS:1-[[4-(CYCLOPROPYLMETHYL)-5-[2-(PYRIDIN-4-YLAMINO)PYRIMIDIN-4-YL]PYRIMIDIN-2-YL]AMINO]-2-METHYL-PROPAN-2-OL'>5QS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enn OCA], [https://pdbe.org/5enn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5enn RCSB], [https://www.ebi.ac.uk/pdbsum/5enn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5enn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Kearney | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kearney EP]] | ||
Current revision
The crystal structure of Human VPS34 in complex with a selective and potent inhibitor
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