5epj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5epj is ON HOLD Authors: Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Ed...)
Current revision (09:38, 2 April 2025) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5epj is ON HOLD
+
==Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866==
-
 
+
<StructureSection load='5epj' size='340' side='right'caption='[[5epj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
Authors: Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5epj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EPJ FirstGlance]. <br>
-
Description: Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5R0:4-~{TERT}-BUTYLBENZOIC+ACID'>5R0</scene>, <scene name='pdbligand=5R5:METHYL+(2~{S})-2-AZANYL-3-OXIDANYL-PROPANOATE'>5R5</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene></td></tr>
-
[[Category: James, L.I]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5epj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5epj OCA], [https://pdbe.org/5epj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5epj RCSB], [https://www.ebi.ac.uk/pdbsum/5epj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5epj ProSAT]</span></td></tr>
-
[[Category: Frye, S.V]]
+
</table>
-
[[Category: Dickson, B.M]]
+
== Function ==
-
[[Category: Min, J]]
+
[https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref>
-
[[Category: Walker, J.R]]
+
== References ==
-
[[Category: Liu, Y]]
+
<references/>
-
[[Category: Bountra, C]]
+
__TOC__
-
[[Category: Tempel, W]]
+
</StructureSection>
-
[[Category: Arrowsmith, C.H]]
+
[[Category: Homo sapiens]]
-
[[Category: Stuckey, J.I]]
+
[[Category: Large Structures]]
-
[[Category: Edwards, A.M]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
[[Category: Bountra C]]
 +
[[Category: Dickson BM]]
 +
[[Category: Edwards AM]]
 +
[[Category: Frye SV]]
 +
[[Category: James LI]]
 +
[[Category: Liu Y]]
 +
[[Category: Min J]]
 +
[[Category: Stuckey JI]]
 +
[[Category: Tempel W]]
 +
[[Category: Walker JR]]

Current revision

Crystal Structure of chromodomain of CBX7 in complex with inhibitor UNC3866

PDB ID 5epj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5epj"
Personal tools