5eqb

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m (Protected "5eqb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5eqb is ON HOLD
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==Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole==
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<StructureSection load='5eqb' size='340' side='right'caption='[[5eqb]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5eqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4k0f 4k0f]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1YN:2-[(2R)-BUTAN-2-YL]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-DICHLOROPHENYL)-2-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZIN-1-YL]PHENYL}-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>1YN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqb OCA], [https://pdbe.org/5eqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqb RCSB], [https://www.ebi.ac.uk/pdbsum/5eqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP51_YEAST CP51_YEAST] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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Authors: Monk, B.C., Tomasiak, T.M., Keniya, M.V., Huschmann, F.U., Tyndall, J.D.A., O'Connell III, J.D., Cannon, R.D., Finer-Morre, J., Stroud, R.M., Center for Structures of Membrane Proteins (CSMP)
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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Description: Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Tyndall, J.D.A]]
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[[Category: Large Structures]]
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[[Category: Cannon, R.D]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Tomasiak, T.M]]
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[[Category: Cannon RD]]
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[[Category: O'Connell Iii, J.D]]
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[[Category: Finer-Morre J]]
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[[Category: Center For Structures Of Membrane Proteins (Csmp)]]
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[[Category: Huschmann FU]]
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[[Category: Monk, B.C]]
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[[Category: Keniya MV]]
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[[Category: Huschmann, F.U]]
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[[Category: Monk BC]]
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[[Category: Keniya, M.V]]
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[[Category: O'Connell III JD]]
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[[Category: Stroud, R.M]]
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[[Category: Stroud RM]]
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[[Category: Finer-Morre, J]]
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[[Category: Tomasiak TM]]
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[[Category: Tyndall JDA]]

Current revision

Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole

PDB ID 5eqb

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