5eqe
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)== | |
| + | <StructureSection load='5eqe' size='340' side='right'caption='[[5eqe]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5eqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EQE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5R8:[4-[(4-METHYL-1,4-DIAZEPAN-1-YL)METHYL]PHENYL]METHANAMINE'>5R8</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eqe OCA], [https://pdbe.org/5eqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eqe RCSB], [https://www.ebi.ac.uk/pdbsum/5eqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eqe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Choline kinase 3D structures|Choline kinase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Dalgarno | + | __TOC__ |
| - | [[Category: Zhou | + | </StructureSection> |
| - | [[Category: Zhu | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dalgarno DC]] | ||
| + | [[Category: Zhou T]] | ||
| + | [[Category: Zhu X]] | ||
Current revision
Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)
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