1a6d

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[[Image:1a6d.gif|left|200px]]
 
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{{Structure
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==THERMOSOME FROM T. ACIDOPHILUM==
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|PDB= 1a6d |SIZE=350|CAPTION= <scene name='initialview01'>1a6d</scene>, resolution 2.6&Aring;
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<StructureSection load='1a6d' size='340' side='right'caption='[[1a6d]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1a6d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6D FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6d OCA], [https://pdbe.org/1a6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6d RCSB], [https://www.ebi.ac.uk/pdbsum/1a6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6d ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6d OCA], [http://www.ebi.ac.uk/pdbsum/1a6d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a6d RCSB]</span>
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[https://www.uniprot.org/uniprot/THSA_THEAC THSA_THEAC] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a6d ConSurf].
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<div style="clear:both"></div>
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'''THERMOSOME FROM T. ACIDOPHILUM'''
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==See Also==
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*[[Chaperonin 3D structures|Chaperonin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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We have determined to 2.6 A resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog of the eukaryotic chaperonin CCT/TRiC shows an (alphabeta)4(alphabeta)4 subunit assembly. Domain folds are homologous to GroEL but form a novel type of inter-ring contact. The domain arrangement resembles the GroEL-GroES cis-ring. Parts of the apical domains form a lid creating a closed conformation. The lid substitutes for a GroES-like cochaperonin that is absent in the CCT/TRiC system. The central cavity has a polar surface implicated in protein folding. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.
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[[Category: Large Structures]]
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==About this Structure==
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1A6D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6D OCA].
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==Reference==
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Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546398 9546398]
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[[Category: Protein complex]]
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[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: Ditzel, L.]]
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[[Category: Ditzel L]]
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[[Category: Huber, H.]]
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[[Category: Huber H]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Loewe, J.]]
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[[Category: Loewe J]]
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[[Category: Steinbacher, S.]]
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[[Category: Steinbacher S]]
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[[Category: Stetter, K O.]]
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[[Category: Stetter K-O]]
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[[Category: Stock, D.]]
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[[Category: Stock D]]
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[[Category: atpase]]
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[[Category: cct]]
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[[Category: group ii chaperonin]]
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[[Category: protein folding]]
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[[Category: thermoplasma acidophilum]]
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[[Category: tric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:34:13 2008''
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Current revision

THERMOSOME FROM T. ACIDOPHILUM

PDB ID 1a6d

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