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5esu
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5esu is ON HOLD Authors: Johnston, J.M., Jirgis, E.N.M., Bashiri, G., Bulloch, E.M.M., Baker, E.N. Description: [[Category: Unreleased Structures]...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP + de-carboxylated 2-oxoglutarate + Isochorismate adduct)== | |
| - | + | <StructureSection load='5esu' size='340' side='right'caption='[[5esu]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5esu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ESU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TOI:(1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-AZANYLIDENE-2-METHYL-1~{H}-PYRIMIDIN-5-YL)METHYL]-4-METHYL-5-[2-[OXIDANYL(PHOSPHONOOXY)PHOSPHORYL]OXYETHYL]-1,3-THIAZOL-3-IUM-2-YL]-1,4-BIS(OXIDANYL)-4-OXIDANYLIDENE-BUTYL]-6-OXIDANYL-5-(3-OXIDANYL-3-OXIDANYLIDENE-PROP-1-EN-2-YL)OXY-CYCLOHEX-3-ENE-1-CARBOXYLIC+ACID'>TOI</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5esu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esu OCA], [https://pdbe.org/5esu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5esu RCSB], [https://www.ebi.ac.uk/pdbsum/5esu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5esu ProSAT]</span></td></tr> |
| - | [[Category: Bashiri | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MEND_MYCTU MEND_MYCTU] Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Baker EN]] | ||
| + | [[Category: Bashiri G]] | ||
| + | [[Category: Bulloch EMM]] | ||
| + | [[Category: Jirgis ENM]] | ||
| + | [[Category: Johnston JM]] | ||
Current revision
Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP + de-carboxylated 2-oxoglutarate + Isochorismate adduct)
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