5eup
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5eup is ON HOLD Authors: Plevock, K.M., Galletta, B.J., Slep, K.C., Rusan, N.M. Description: Structure of the Drosophila melanogaster CP190 BTB dom...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the Drosophila melanogaster CP190 BTB domain== | |
| - | + | <StructureSection load='5eup' size='340' side='right'caption='[[5eup]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5eup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EUP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eup OCA], [https://pdbe.org/5eup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eup RCSB], [https://www.ebi.ac.uk/pdbsum/5eup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eup ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CP190_DROME CP190_DROME] Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may directly bind to insulator DNA at sites distinct from those recognized by su(Hw). Required during embryogenesis for axial expansion, an actin/myosin dependent process that distributes the dividing nuclei along the anterior-posterior axis of the syncytial embryo. Does not appear to play a crucial role in organizing centrosomal microtubules during mitosis.<ref>PMID:14996941</ref> <ref>PMID:15574329</ref> <ref>PMID:16051175</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Drosophila melanogaster]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Galletta BJ]] | ||
| + | [[Category: Plevock KM]] | ||
| + | [[Category: Rusan NM]] | ||
| + | [[Category: Slep KC]] | ||
Current revision
Structure of the Drosophila melanogaster CP190 BTB domain
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