5flu

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(New page: '''Unreleased structure''' The entry 5flu is ON HOLD until Paper Publication Authors: Hospenthal, M.K., Redzej, A., Dodson, K., Ukleja, M., Frenz, B., Hultgren, S.J., DiMaio, F., Egelma...)
Current revision (06:56, 19 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5flu is ON HOLD until Paper Publication
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==Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin==
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<SX load='5flu' size='340' side='right' viewer='molstar' caption='[[5flu]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5flu]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FLU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5flu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5flu OCA], [https://pdbe.org/5flu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5flu RCSB], [https://www.ebi.ac.uk/pdbsum/5flu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5flu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAPA_ECOLX PAPA_ECOLX] Polymerizes to form the thick (6.8 nm in diameter) rod of the pilus (also called fimbria). The rod is a right-handed helical cylinder with 3.28 PapA subunits per turn. Pili are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria to colonize the epithelium of specific host organs.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Types 1 and P pili are prototypical bacterial cell-surface appendages playing essential roles in mediating adhesion of bacteria to the urinary tract. These pili, assembled by the chaperone-usher pathway, are polymers of pilus subunits assembling into two parts: a thin, short tip fibrillum at the top, mounted on a long pilus rod. The rod adopts a helical quaternary structure and is thought to play essential roles: its formation may drive pilus extrusion by preventing backsliding of the nascent growing pilus within the secretion pore; the rod also has striking spring-like properties, being able to uncoil and recoil depending on the intensity of shear forces generated by urine flow. Here, we present an atomic model of the P pilus generated from a 3.8 A resolution cryo-electron microscopy reconstruction. This structure provides the molecular basis for the rod's remarkable mechanical properties and illuminates its role in pilus secretion.
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Authors: Hospenthal, M.K., Redzej, A., Dodson, K., Ukleja, M., Frenz, B., Hultgren, S.J., DiMaio, F., Egelman, E.H., Waksman, G.
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Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.,Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G Cell. 2015 Dec 22. pii: S0092-8674(15)01568-8. doi: 10.1016/j.cell.2015.11.049. PMID:26724865<ref>PMID:26724865</ref>
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Description: Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Hospenthal, M.K]]
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<div class="pdbe-citations 5flu" style="background-color:#fffaf0;"></div>
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[[Category: Egelman, E.H]]
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[[Category: Waksman, G]]
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==See Also==
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[[Category: Redzej, A]]
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*[[Pilin 3D structures|Pilin 3D structures]]
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[[Category: Hultgren, S.J]]
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== References ==
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[[Category: Frenz, B]]
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<references/>
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[[Category: Ukleja, M]]
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__TOC__
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[[Category: Dodson, K]]
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</SX>
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[[Category: Dimaio, F]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: DiMaio F]]
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[[Category: Dodson K]]
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[[Category: Egelman EH]]
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[[Category: Frenz B]]
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[[Category: Hospenthal MK]]
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[[Category: Hultgren SJ]]
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[[Category: Redzej A]]
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[[Category: Ukleja M]]
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[[Category: Waksman G]]

Current revision

Structure of a Chaperone-Usher pilus reveals the molecular basis of rod uncoilin

5flu, resolution 3.80Å

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