This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1a9v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:22, 13 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1a9v.gif|left|200px]]
 
-
{{Structure
+
==TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES==
-
|PDB= 1a9v |SIZE=350|CAPTION= <scene name='initialview01'>1a9v</scene>
+
<StructureSection load='1a9v' size='340' side='right'caption='[[1a9v]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1a9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A9V FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [https://pdbe.org/1a9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB], [https://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a9v ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a9v OCA], [http://www.ebi.ac.uk/pdbsum/1a9v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a9v RCSB]</span>
+
[https://www.uniprot.org/uniprot/ALL2_DERPT ALL2_DERPT]
-
}}
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
'''TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES'''
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/1a9v_consurf.spt"</scriptWhenChecked>
-
==Overview==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
Sensitization to indoor allergens, especially those of the house dust mite, is strongly correlated with the development of asthma. We report the tertiary structure of the major house dust mite allergen, Der p 2, determined by NMR methods. The structure of Der p 2 is a beta-barrel and is composed of two three-stranded antiparallel beta-pleated sheets. This arrangement of beta-strands is similar to the immunoglobulin fold with respect to the orientation of the two sheets and the interactions of the strands. However, the three-dimensional structure of Der p 2 aligns equivalently with a number of proteins from different families within the immunoglobulin superfamily. The structural homology with the highest significance score from analysis by DALI is to Der f 2. Although Der p 2 and Der f 2 are 87% identical in amino acid sequence, they align in three dimensions rather poorly (4.85 A RMSD; Z-score, 8.58). This unexpected finding is likely due to the different solution conditions used during structure determination by NMR for both proteins. While the structural comparisons did not elucidate a clear homologue for the function of Der p 2 in mites, we report that Der p 2 is sequentially homologous to esr16. This is a protein from moths that is expressed coincident with molting. Thus, this homology has important ramifications for the study of mite allergy. The structure of Der p 2 provides a useful tool in the design of recombinant immunotherapeutics for the group 2 allergens.
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a9v ConSurf].
-
1A9V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A9V OCA].
+
<div style="clear:both"></div>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies., Mueller GA, Benjamin DC, Rule GS, Biochemistry. 1998 Sep 15;37(37):12707-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9737847 9737847]
+
[[Category: Dermatophagoides pteronyssinus]]
[[Category: Dermatophagoides pteronyssinus]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Benjamin, D C.]]
+
[[Category: Benjamin DC]]
-
[[Category: Mueller, G A.]]
+
[[Category: Mueller GA]]
-
[[Category: Rule, G S.]]
+
[[Category: Rule GS]]
-
[[Category: allergen]]
+
-
[[Category: immunoglobulin fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:36:26 2008''
+

Current revision

TERTIARY STRUCTURE OF THE MAJOR HOUSE DUST MITE ALLERGEN DER P 2, NMR, 10 STRUCTURES

PDB ID 1a9v

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1a9v"
Personal tools