Adapter molecule crk

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<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (grey) complex with proline-rich peptide (green) (PDB entry [[1cka]])' scene=''>
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<StructureSection load='1cka' size='350' side='right' caption='Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry [[1cka]])' scene='57/573988/Cv/1'>
== Function ==
== Function ==
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'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.
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'''Adapter molecule crk''' (Crk) ('''C'''T10 '''R'''egulatior of '''K'''inase) or '''p38''' is a proto-oncogene which participates in the Reelin signaling cascade. Crk binds to several tyrosine-phosphorylated proteins.<ref>PMID:12086608</ref> See also [[SRC]] and [[Oncogenes & Tumor Suppressor Genes]].
== Structural highlights ==
== Structural highlights ==
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Crk domains include several N-terminal SH2 and C-terminal SH3 domains.
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Crk domains include several N-terminal SH2 and C-terminal SH3 domains. <scene name='57/573988/Cv/4'>Mouse Crk N terminal SH3 domain complex with proline-rich peptide</scene> ([[1cka]])<ref>PMID:7735837</ref> is shown.
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</StructureSection>
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==3D structures of adpter molecule crk==
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==3D structures of adapter molecule crk==
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[[Adapter molecule crk 3D structures]]
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[[1m30]], [[1m3a]], [[1m3b]], [[1m3c]] – mCrk N terminal SH3 (mutant) – mouse - NMR<br />
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</StructureSection>
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[[2ggr]] – mCrk C terminal SH3 - NMR<br />
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[[2l3p]], [[2l3q]], [[2l3s]] – Crk residues 220-297 – chicken – NMR<br />
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[[1cka]], [[1ckb]] – mCrk N terminal SH3 + proline-rich peptide<br />
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[[1b07]] – mCrk N terminal SH3 + SH3 peptoid inhibitor<br />
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[[1ju5]] – hCrk SH2 + phosphopeptide + Abl SH3 - human<br />
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== References ==
 
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of mouse Crk N terminal SH3 domain (magenta) complex with proline-rich peptide (green) (PDB entry 1cka)

Drag the structure with the mouse to rotate


References

  1. ↑ Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ. Molecular architecture and functional model of the endocytic AP2 complex. Cell. 2002 May 17;109(4):523-35. PMID:12086608
  2. ↑ Wu X, Knudsen B, Feller SM, Zheng J, Sali A, Cowburn D, Hanafusa H, Kuriyan J. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure. 1995 Feb 15;3(2):215-26. PMID:7735837

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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