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4ucj

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==X-ray structure and activities of an essential Mononegavirales L- protein domain==
==X-ray structure and activities of an essential Mononegavirales L- protein domain==
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<StructureSection load='4ucj' size='340' side='right' caption='[[4ucj]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
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<StructureSection load='4ucj' size='340' side='right'caption='[[4ucj]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ucj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UCJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ucj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_metapneumovirus Human metapneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UCJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uci|4uci]], [[4uck|4uck]], [[4ucl|4ucl]], [[4ucy|4ucy]], [[4ucz|4ucz]], [[4ud0|4ud0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ucj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucj OCA], [https://pdbe.org/4ucj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ucj RCSB], [https://www.ebi.ac.uk/pdbsum/4ucj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ucj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ucj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ucj OCA], [http://pdbe.org/4ucj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ucj RCSB], [http://www.ebi.ac.uk/pdbsum/4ucj PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/L_HMPVC L_HMPVC]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
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[https://www.uniprot.org/uniprot/Q91L20_9MONO Q91L20_9MONO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ucj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ucj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canard, B]]
 
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[[Category: Collet, A]]
 
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[[Category: Debart, F]]
 
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[[Category: Decroly, E]]
 
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[[Category: Grimes, J M]]
 
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[[Category: Paesen, G C]]
 
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[[Category: Sallamand, C]]
 
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[[Category: Vasseur, J J]]
 
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[[Category: Adenosine]]
 
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[[Category: Capping]]
 
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[[Category: Gtp]]
 
[[Category: Human metapneumovirus]]
[[Category: Human metapneumovirus]]
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[[Category: L protein]]
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[[Category: Large Structures]]
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[[Category: Methyltransferase]]
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[[Category: Canard B]]
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[[Category: Rossmann]]
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[[Category: Collet A]]
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[[Category: S-adenosyl methionine]]
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[[Category: Debart F]]
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[[Category: Transferase]]
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[[Category: Decroly E]]
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[[Category: Triphosphatase]]
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[[Category: Grimes JM]]
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[[Category: Paesen GC]]
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[[Category: Sallamand C]]
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[[Category: Vasseur JJ]]

Current revision

X-ray structure and activities of an essential Mononegavirales L- protein domain

PDB ID 4ucj

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