5e8f
From Proteopedia
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==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D== | ==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D== | ||
| - | <StructureSection load='5e8f' size='340' side='right' caption='[[5e8f]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='5e8f' size='340' side='right'caption='[[5e8f]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E8F FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8f OCA], [https://pdbe.org/5e8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e8f RCSB], [https://www.ebi.ac.uk/pdbsum/5e8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8f ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN]] Progressive cone dystrophy;Achromatopsia. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This study shows that the prenylated C-terminus of RPGR can bind to PDE6delta with high affinity, suggesting two distinct binding sites of the RPGR/PDE6delta complex. The serine residue at the -3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6delta towards ciliary prenylated cargo. [Image: see text] | ||
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| + | The N- and C-terminal ends of RPGR can bind to PDE6delta.,Fansa EK, O'Reilly NJ, Ismail S, Wittinghofer A EMBO Rep. 2015 Dec;16(12):1583-5. doi: 10.15252/embr.201541404. Epub 2015 Nov 9. PMID:26553937<ref>PMID:26553937</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5e8f" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Fansa EK]] |
| - | [[Category: | + | [[Category: Ismail SA]] |
| - | [[Category: | + | [[Category: O'Reilly NJ]] |
| - | [[Category: | + | [[Category: Wittinghofer A]] |
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Current revision
Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D
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