Agrin

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<StructureSection load='' size='350' side='right' caption='Chicken agrin (PDB code [[3i70]]).' scene='41/417482/Cv/2'>
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__TOC__
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== Function ==
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[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. <ref>PMID:7852425</ref>
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<StructureSection load='3i70' size='350' side='right' caption='Chicken agrin (PDB code [[3i70]]).' scene='Agrin/Cv/1'>
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== Relevance ==
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== Function ==
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Agr is an inducer of mammalian heart regeneration<ref>PMID:28581497</ref>.
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[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors.
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== Disease ==
== Disease ==
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Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor.
Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor.
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</StructureSection>
 
== 3D Structures of Agrin ==
== 3D Structures of Agrin ==
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[[Agrin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[3i70]], [[1pxu]] – cNtA – chicken<br />
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[[1pz7]], [[1pz8]], [[1pz9]] – cAgr<br />
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[[1q56]] – cAgr LMB G3+Ca – NMR<br />
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[[1jb3]], [[1jc7]] – cAgr LMB<br />
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[[3pve]] – Agr LMB G2 - mouse<br />
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[[3v65]], [[3v64]] – Agr LMB G3 + Low-density lipoprotein receptor-related protein 4 - rat
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Chicken agrin (PDB code 3i70).

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References

  1. ↑ Tsen G, Halfter W, Kroger S, Cole GJ. Agrin is a heparan sulfate proteoglycan. J Biol Chem. 1995 Feb 17;270(7):3392-9. PMID:7852425
  2. ↑ Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5. PMID:28581497 doi:http://dx.doi.org/10.1038/nature22978

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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