Ankyrin
From Proteopedia
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*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br /> | *'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br /> | ||
| - | '''Gankyrin''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats. | + | '''Gankyrin''' or '''26S proteasome non-ATPase regulatory subunit 10''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats. |
== Disease == | == Disease == | ||
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Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref> | Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref> | ||
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| + | == 3D Structures of ankyrin == | ||
| + | [[Ankyrin 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Ankyrin == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Ankyrin | ||
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| - | **[[1n11]] – hANK-1 D34 region – human<br /> | ||
| - | **[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br /> | ||
| - | **[[3f59]] – hANK-1 spectrin-binding domain<br /> | ||
| - | **[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br /> | ||
| - | **[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br /> | ||
| - | **[[4o6x]] - hANK-3 death domain<br /> | ||
| - | **[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br /> | ||
| - | **[[4rlv]] - hANK-1 + hANK-2<br /> | ||
| - | **[[3so8]] – hANK-A residues 149-310<br /> | ||
| - | **[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br /> | ||
| - | **[[1svx]] – dANK + maltose-binding protein<br /> | ||
| - | **[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br /> | ||
| - | **[[2aja]] – ANK – Legionella pneumophila<br /> | ||
| - | **[[3hra]] – ANK – Enterococus faecalis<br /> | ||
| - | **[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br /> | ||
| - | |||
| - | *Gankyrin | ||
| - | **[[1uoh]], [[1qym]] – hGANK<br /> | ||
| - | **[[1tr4]] – hGANK – NMR<br /> | ||
| - | **[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Michaely P, Tomchick DR, Machius M, Anderson RG. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646
- ↑ Mosavi LK, Minor DL Jr, Peng ZY. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16029-34. Epub 2002 Dec 2. PMID:12461176 doi:http://dx.doi.org/10.1073/pnas.252537899
