This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5dj4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:24, 6 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Leucine-bound Sestrin2 from Homo sapiens==
==Leucine-bound Sestrin2 from Homo sapiens==
-
<StructureSection load='5dj4' size='340' side='right' caption='[[5dj4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='5dj4' size='340' side='right'caption='[[5dj4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5dj4]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJ4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5dj4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DJ4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.697&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dj4 OCA], [http://pdbe.org/5dj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5dj4 PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dj4 OCA], [https://pdbe.org/5dj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dj4 RCSB], [https://www.ebi.ac.uk/pdbsum/5dj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dj4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SESN2_HUMAN SESN2_HUMAN]] Involved in the reduction of peroxiredoxins.<ref>PMID:15105503</ref>
+
[https://www.uniprot.org/uniprot/SESN2_HUMAN SESN2_HUMAN] Involved in the reduction of peroxiredoxins.<ref>PMID:15105503</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Eukaryotic cells coordinate growth with the availability of nutrients through mTOR complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag GTPases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine sensor. We present the 2.7-A crystal structure of Sestrin2 in complex with leucine. Leucine binds through a single pocket that coordinates its charged functional groups and confers specificity for the hydrophobic side chain. A loop encloses leucine and forms a lid-latch mechanism required for binding. A structure-guided mutation in Sestrin2 that decreases its affinity for leucine leads to a concomitant increase in the leucine concentration required for mTORC1 activation in cells. These results provide a structural mechanism of amino acid sensing by the mTORC1 pathway.
+
-
 
+
-
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.,Saxton RA, Knockenhauer KE, Wolfson RL, Chantranupong L, Pacold ME, Wang T, Schwartz TU, Sabatini DM Science. 2015 Nov 19. pii: aad2087. PMID:26586190<ref>PMID:26586190</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 5dj4" style="background-color:#fffaf0;"></div>
+
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Knockenhauer, K E]]
+
[[Category: Homo sapiens]]
-
[[Category: Saxton, R A]]
+
[[Category: Large Structures]]
-
[[Category: Schwartz, T U]]
+
[[Category: Knockenhauer KE]]
-
[[Category: Amino-acid]]
+
[[Category: Saxton RA]]
-
[[Category: Leucine]]
+
[[Category: Schwartz TU]]
-
[[Category: Mtor]]
+
-
[[Category: Sensing]]
+
-
[[Category: Signaling protein]]
+

Current revision

Leucine-bound Sestrin2 from Homo sapiens

PDB ID 5dj4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dj4"
Personal tools