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5ae1

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==Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460==
==Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460==
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<StructureSection load='5ae1' size='340' side='right' caption='[[5ae1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5ae1' size='340' side='right'caption='[[5ae1]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ae1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AE1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AE1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ae1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cavia_porcellus Cavia porcellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AE1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B2Z:(3-(2-FLUOROPHENYL)-N-(1-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)ETHYL)BUTANAMIDE)'>B2Z</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5adz|5adz]], [[5ae2|5ae2]], [[5ae3|5ae3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2Z:(3-(2-FLUOROPHENYL)-N-(1-(2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)ETHYL)BUTANAMIDE)'>B2Z</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ae1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ae1 OCA], [https://pdbe.org/5ae1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ae1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ae1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ae1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ae1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ae1 OCA], [http://pdbe.org/5ae1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ae1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ae1 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADAS_CAVPO ADAS_CAVPO]] Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.<ref>PMID:23112191</ref>
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[https://www.uniprot.org/uniprot/ADAS_CAVPO ADAS_CAVPO] Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.<ref>PMID:23112191</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alkylglycerone-phosphate synthase]]
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[[Category: Cavia porcellus]]
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[[Category: Aliverti, A]]
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[[Category: Large Structures]]
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[[Category: Benjamin, D I]]
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[[Category: Aliverti A]]
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[[Category: Mai, A]]
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[[Category: Benjamin DI]]
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[[Category: Marrocco, B]]
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[[Category: Mai A]]
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[[Category: Mattevi, A]]
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[[Category: Marrocco B]]
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[[Category: Nenci, S]]
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[[Category: Mattevi A]]
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[[Category: Nomura, D K]]
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[[Category: Nenci S]]
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[[Category: Piano, V]]
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[[Category: Nomura DK]]
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[[Category: Valente, S]]
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[[Category: Piano V]]
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[[Category: Cancer]]
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[[Category: Valente S]]
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[[Category: Ether phospholipid]]
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[[Category: Flavin]]
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[[Category: Transferase]]
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Current revision

Ether Lipid-Generating Enzyme AGPS in complex with inhibitor ZINC69435460

PDB ID 5ae1

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