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Arginase

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<StructureSection load='1hqg' size='350' side='right' caption='Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code [[1hqg]]).' scene='59/593950/Cv/1'>
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<StructureSection load='1hqg' size='400' side='right' caption='Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code [[1hqg]]).' scene='59/593950/Cv/1'>
== Function ==
== Function ==
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'''Arginase''' (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning.
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'''Arginase''' (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning.<ref>PMID:18360740</ref>
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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The manganese ions are located at the bottom of a 15A cleft. The proposed reaction mechanism involves H141, D128, E277 in rat. <scene name='59/593950/Cv/3'>Active site</scene>.
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The manganese ions are located at the bottom of a 15A cleft. <scene name='59/593950/Cv/4'>Active site</scene>. The proposed reaction mechanism involves <scene name='59/593950/Cv/5'>H141, D128, E277</scene> in rat.<ref>PMID:11258880</ref>
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</StructureSection>
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==3D structures of arginase==
==3D structures of arginase==
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[[Arginase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Arginase
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**[[3tf3]] – hArg 1 - human <br />
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**[[2ef4]], [[2ef5]], [[2eiv]] – Arg – ''Thermus thermophilus'' <br />
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**[[4rhi]], [[4rhj]], [[4rhk]] – TbArg – ''Trypanosoma brucei''<br />
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*Mn containing arginase
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**[[1rla]], [[2rla]] – rArg + Mn – rat<br />
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**[[3rla]], [[4rla]], [[5rla]], [[1hqx]], [[1p8m]], [[1p8n]], [[1p8o]], [[1p8p]], [[1p8q]], [[1p8r]], [[1p8s]], [[1ta1]], [[1tbh]], [[1tbj]], [[1tbl]], [[3e8q]], [[3e8z]] – rArg (mutant) + Mn <br />
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**[[1wva]], [[2pha]], [[2zav]] – hArg 1 + Mn <br />
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**[[1wvb]] – hArg 1 (mutant) + Mn <br />
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**[[1cev]], [[2cev]] – BcArg + Mn – ''Bacillus caldovelox''<br />
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**[[4g3h]] – Arg + Mn – ''Helicobacter pylori''<br />
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**[[4ity]] – LmArg + Mn – ''Leishmania mexicana''<br />
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**[[4q3p]] – SmArg + Mn – ''Schistosoma mansoni''<br />
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**[[4rhl]], [[4rhm]], [[4rhq]] – TbArg (mutant) + Mn <br />
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* ''Mn containing arginase complexes''
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**[[1d3v]], [[1hq5]] – rArg + Mn + Arg analog<br />
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**[[1hqf]], [[1hqh]] – rArg + Mn + hydroxyl-Arg <br />
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**[[1hqg]] – rArg (mutant) + Mn + ornithine + urea<br />
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**[[1r1o]], [[1t4p]], [[1t4r]], [[1t4t]], [[1t5f]] – rArg + Mn + inhibior<br />
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**[[1t4s]] – rArg + Mn + valine<br />
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**[[1t5g]] – rArg + Mn + Arg <br />
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**[[1zpe]], [[1zpg]] – rArg (mutant) + Mn + alkylamine derivative<br />
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**[[3e9b]] – rArg (mutant) + Mn + Br-ethyl cysteine<br />
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**[[2aeb]], [[2pll]] – hArg 1 + Mn + Arg analog<br />
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**[[2pho]] – hArg 1 + Mn + thiosemicarbazide<br />
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**[[3dj8]] – hArg 1 + Mn + amino-epoxy octanoic acid<br />
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**[[3e6k]], [[3e6v]] – hArg 1 (mutant) + Mn + Arg analog<br />
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**[[3f80]] – hArg 1 + Mn + nitro-norleucine<br />
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**[[3kv2]], [[3lp7]] – hArg 1 + Mn + nor-ω-hydroxy-Arg<br />
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**[[3gmz]] – hArg 1 + Mn + ornithine <br />
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**[[3gn0]] – hArg 1 + Mn + ornithine derivative<br />
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**[[3lp4]] – hArg 1 + Mn + lysine <br />
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**[[3mfv]], [[3mfw]] – hArg 1 + Mn + histidine derivative<br />
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**[[3mjl]] – hArg 1 + Mn + amino-imidazole<br />
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**[[3sjt]], [[3skk]], [[4hww]], [[4hxq]], [[4ie1]] – hArg 1 + Mn + inhibitor<br />
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**[[4fci]] – hArg 1 + Mn + amino-guanidino propionate<br />
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**[[3cev]] – BcArg + Mn + Arg <br />
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**[[5cev]] – BcArg + Mn + Lys <br />
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**[[4iu0]], [[4iu1]], [[4iu4]] – LmArg + Mn + inhibitor<br />
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**[[4iu5]] – LmArg + Mn + ornithine <br />
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**[[4q3q]], [[4q3r]], [[4q3s]], [[4q3t]], [[4q3u]], [[4q3v]] – SmArg + Mn + inhibitor<br />
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**[[4q40]], [[4q41]] – SmArg + Mn + amino acid<br />
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**[[4q42]] – SmArg + Mn + ornithine <br />
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*Co containing arginase
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**[[3th7]], [[3the]] – hArg 1 + Co <br />
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**[[3thh]] – hArg 1 + Co + Arg analog<br />
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**[[3thj]] – hArg 1 + Co + ornithine <br />
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**[[4fck]] – hArg 1 + Co + amino-guanidino propionate<br />
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*Ni containing arginase
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**[[4gsm]] – hArg 1 + Ni<br />
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**[[4gsv]] – hArg 1 + Ni + Arg analog<br />
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*Zn containing arginase
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**[[4gsz]] – hArg 1 + Zn + Arg analog<br />
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*Mn and Zn containing arginase
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**[[4gwc]] – hArg 1 + Mn + Zn<br />
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**[[4gwd]] – hArg 1 + Mn + Zn + Arg analog<br />
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*Arginase 2
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**[[1pq3]] – hArg 2+ Mn <br />
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**[[4hze]], [[4i06]], [[4ie2]], [[4ie3]], [[4ixu]], [[4ixv]] – hArg 2 + Mn + inhibitor<br />
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}}
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== References ==
== References ==

Current revision

Structure of rat arginase containing Mn+2 (purple) complex with ornithine (cyan) and urea (yellow) (PDB code 1hqg).

Drag the structure with the mouse to rotate

References

  1. ↑ Dowling DP, Di Costanzo L, Gennadios HA, Christianson DW. Evolution of the arginase fold and functional diversity. Cell Mol Life Sci. 2008 Jul;65(13):2039-55. doi: 10.1007/s00018-008-7554-z. PMID:18360740 doi:http://dx.doi.org/10.1007/s00018-008-7554-z
  2. ↑ Cox JD, Cama E, Colleluori DM, Pethe S, Boucher JL, Mansuy D, Ash DE, Christianson DW. Mechanistic and metabolic inferences from the binding of substrate analogues and products to arginase. Biochemistry. 2001 Mar 6;40(9):2689-701. PMID:11258880

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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