5emp

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'''Unreleased structure'''
 
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The entry 5emp is ON HOLD until Paper Publication
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==Transcription factor GRDBD and mmGRE complex==
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<StructureSection load='5emp' size='340' side='right'caption='[[5emp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5emp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EMP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5emp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emp OCA], [https://pdbe.org/5emp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5emp RCSB], [https://www.ebi.ac.uk/pdbsum/5emp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5emp ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref>
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Authors: Lian, T., Jin, J., Su, X.
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==See Also==
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*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]
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Description: Transcription factor and DNA complex
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Su, X]]
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__TOC__
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[[Category: Jin, J]]
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</StructureSection>
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[[Category: Lian, T]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Jin J]]
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[[Category: Lian T]]
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[[Category: Su X]]

Current revision

Transcription factor GRDBD and mmGRE complex

PDB ID 5emp

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OCA

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