5ex7

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'''Unreleased structure'''
 
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The entry 5ex7 is ON HOLD
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==Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA==
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<StructureSection load='5ex7' size='340' side='right'caption='[[5ex7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Wang, Y., Yu, Z., Wang, M., Liu, C.P., Yang, N., Xu, R.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ex7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila Drosophila] and [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EX7 FirstGlance]. <br>
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Description: Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ex7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ex7 OCA], [https://pdbe.org/5ex7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ex7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ex7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ex7 ProSAT]</span></td></tr>
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[[Category: Wang, M]]
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</table>
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[[Category: Yu, Z]]
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== Function ==
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[[Category: Wang, Y]]
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[https://www.uniprot.org/uniprot/BRAT_DROME BRAT_DROME] Plays a central role in translation repression of hb mRNA by being recruited by nos and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR. Probably recruited by other proteins to repress translation of other mRNAs in other tissues. Involved in the regulation of ribosomal RNA synthesis and cell growth. Participates in abdominal segmentation and imaginal disk development. Involved in brain tumor suppression, by acting as a growth suppressor in the larval brain.<ref>PMID:11274060</ref> <ref>PMID:11807032</ref>
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[[Category: Xu, R.M]]
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== References ==
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[[Category: Liu, C.P]]
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<references/>
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[[Category: Yang, N]]
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__TOC__
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</StructureSection>
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[[Category: Drosophila]]
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[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
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[[Category: Liu CP]]
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[[Category: Wang M]]
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[[Category: Wang Y]]
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[[Category: Xu RM]]
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[[Category: Yang N]]
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[[Category: Yu Z]]

Current revision

Crystal structure of Brat NHL domain in complex with an 8-nt hunchback mRNA

PDB ID 5ex7

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OCA

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