1agq

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[[Image:1agq.gif|left|200px]]
 
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{{Structure
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==GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT==
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|PDB= 1agq |SIZE=350|CAPTION= <scene name='initialview01'>1agq</scene>, resolution 1.90&Aring;
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<StructureSection load='1agq' size='340' side='right'caption='[[1agq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1agq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AGQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [https://pdbe.org/1agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB], [https://www.ebi.ac.uk/pdbsum/1agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1agq ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1agq OCA], [http://www.ebi.ac.uk/pdbsum/1agq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1agq RCSB]</span>
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[https://www.uniprot.org/uniprot/GDNF_RAT GDNF_RAT] Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron.<ref>PMID:10828539</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ag/1agq_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1agq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
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==About this Structure==
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X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding.,Eigenbrot C, Gerber N Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:9187648<ref>PMID:9187648</ref>
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1AGQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding., Eigenbrot C, Gerber N, Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187648 9187648]
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</div>
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<div class="pdbe-citations 1agq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Eigenbrot C]]
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[[Category: Eigenbrot, C.]]
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[[Category: Gerber N]]
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[[Category: Gerber, N.]]
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[[Category: cystine knot]]
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[[Category: growth factor]]
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[[Category: neurotrophic factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:39:51 2008''
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Current revision

GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT

PDB ID 1agq

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