Avirulence protein
From Proteopedia
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| - | + | <StructureSection load='2nun' size='350' side='right' caption='Avirulence protein complex with ADP (stick model) and Tris (PDB code [[2nun]]).' scene='51/510249/Cv/1'> | |
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| - | <StructureSection load='2nun' size='350' side='right' caption='Avirulence protein complex with ADP (stick model) and Tris (PDB code [[2nun]]).' scene=''> | + | |
| - | '''Avirulence protein''' (Avr) are produced by plant pathogens which subvert host cell biology upon infection. Avrs are small proteins which are recognized by the host cell resistance proteins. Avrs are effectors involved in pathogenicity. They are triggering the plant immune system. Avr genes are subject to high-speed diversifying selection allowing the pathogen to diversify its effector repertoire and thus escape recognition by the cell resistance mechanism. For more details see<br /> | + | '''Avirulence protein''' (Avr) are produced by plant pathogens which subvert host cell biology upon infection. Avrs are small proteins which are recognized by the host cell resistance proteins. Avrs are effectors involved in pathogenicity. They are triggering the plant immune system. Avr genes are subject to high-speed diversifying selection allowing the pathogen to diversify its effector repertoire and thus escape recognition by the cell resistance mechanism.<ref>PMID:14694194</ref> For more details see<br /> |
*[[Type III effector AvrB complexed with ADP]]<br /> | *[[Type III effector AvrB complexed with ADP]]<br /> | ||
*[[Type III effector AvrB complexed with a high-affinity RIN4 peptide]] | *[[Type III effector AvrB complexed with a high-affinity RIN4 peptide]] | ||
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| + | == Structural highlights == | ||
| + | <scene name='51/510249/Cv/4'>ADP binding site</scene> in Avirulence protein (PDB code [[2nun]]).<ref>PMID:17397263</ref> Water molecules are shown as red spheres. | ||
==3D structures of avirulence protein== | ==3D structures of avirulence protein== | ||
| + | [[Avirulence protein 3D structures]] | ||
| - | + | </StructureSection> | |
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== References == | == References == | ||
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[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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References
- ↑ Zhu M, Shao F, Innes RW, Dixon JE, Xu Z. The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):302-7. Epub 2003 Dec 23. PMID:14694194 doi:10.1073/pnas.2036536100
- ↑ Desveaux D, Singer AU, Wu AJ, McNulty BC, Musselwhite L, Nimchuk Z, Sondek J, Dangl JL. Type III effector activation via nucleotide binding, phosphorylation, and host target interaction. PLoS Pathog. 2007 Mar;3(3):e48. PMID:17397263 doi:10.1371/journal.ppat.0030048
