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Aminomutase

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<StructureSection load='2ohy' size='340' side='right' caption='Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code [[2ohy]])' scene='71/715468/Cv/1'>
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<StructureSection load='' size='340' side='right' caption='Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code [[2ohy]])' scene='71/715468/Cv/1'>
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'''Aminomutases''' catalyze the exchange of hydrogen atom and an amine substituent on a neighboring carbon atom.<ref>PMID:17516659</ref>
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'''Aminomutases''' catalyze the exchange of hydrogen atom and an amine substituent on a neighboring carbon atom.<ref name="Ad">PMID:17516659</ref>
*'''Phenylalanine aminomutase''' (PAM) catalyzes the reversible conversion of L-phenylalanine to ammonia and trans-cinnamic acid. Ala-Ser-Gly derived chromophore is a cofactor.
*'''Phenylalanine aminomutase''' (PAM) catalyzes the reversible conversion of L-phenylalanine to ammonia and trans-cinnamic acid. Ala-Ser-Gly derived chromophore is a cofactor.
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== Structural highlights ==
== Structural highlights ==
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TAM active site residues facilitate the deprotonation/reprotonation reaction. <scene name='71/715468/Cv/2'>The active site</scene> includes residues from both monomers in Tyrosine aminomutase (PDB code [[2ohy]]).
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TAM active site residues facilitate the deprotonation/reprotonation reaction. <scene name='71/715468/Cv/3'>The active site</scene> includes residues from both monomers in Tyrosine aminomutase (PDB code [[2ohy]]).<ref name="Ad">PMID:17516659</ref>
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</StructureSection>
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==3D structures of aminomutase==
==3D structures of aminomutase==
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[[Aminomutase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Phenylalanine aminomutase
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**[[4c5u]], [[4c6g]] – TwPAM (mutant) – ''Taxus wallichiana''<br />
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**[[1y2m]], [[1t6p]] – RtPAM – ''Rhodosporidium toruloides''<br />
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*Phenylalanine aminomutase complexes
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**[[4v2q]], [[4v2r]], [[4bab]], [[2yii]] – TwPAM + peptide derived chromophore <br />
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**[[4baa]] – TwPAM (mutant) + peptide derived chromophore <br />
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**[[4c5r]] – TwPAM + peptide derived chromophore + phenylpropanoate derivative<br />
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**[[4c5s]] – TwPAM (mutant) + peptide derived chromophore + phenylpropanoate derivative<br />
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**[[4cq5]] – TwPAM (mutant) + peptide derived chromophore + phenylethylenecarboxylate<br />
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**[[3nz4]] – PAM + peptide derived chromophore + phenylethylenecarboxylate – Taxus canadensis<br />
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**[[3unv]] – PAM + peptide derived chromophore + phenylpropanoate derivative + phenylalanine – ''Pantoea agglomerans'' <br />
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**[[3czo]], [[2nyn]] – PAM + peptide derived chromophore – ''Anabaena variabilis''<br />
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**[[2nyf]] – PAM + peptide derived chromophore – ''Nostoc punctiforme''<br />
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**[[1w27]] – PAM + peptide derived chromophore – ''Petroselinum crispum''<br />
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**[[1t6j]] – RtPAM + carboxycinnamic acid<br />
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*Tyrosine-2,3-aminomutase complexes
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**[[2ohy]] – SgTAM + peptide derived chromophore – ''Streptomyces globisporus''<br />
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**[[3kdy]] – SgTAM (mutant) + peptide derived chromophore <br />
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**[[3kdz]] – SgTAM (mutant) + peptide derived chromophore + tyrosine<br />
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**[[2rjr]], [[2rjs]] – SgTAM + peptide derived chromophore + substrate mimic<br />
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**[[2qve]] – SgTAM + peptide derived chromophore + substrate mimic inhibitor<br />
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*Ornithine-4,5-aminomutase complexes
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**[[3koy]], [[3koz]] – CsORAS + CsORAE + cobalamine + deoxyadenosine + ornithine derivative – ''Clostridium stricklandii''<br />
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**[[3kp0]], [[3kox]] – CsORAS + CsORAE + cobalamine + deoxyadenosine + 2,4-diaminobutyrate<br />
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**[[3kow]], [[3kp1]] – CsORAS + CsORAE + cobalamine + deoxyadenosine + PLP<br />
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*Lysine-2,3-aminomutase complexes
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**[[2a5h]] – LAM + SAM + Zn + FeS4 + PLP + lysine – ''Clostridium subterminale''<br />
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*D-lysine-5,6-aminomutase complexes
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**[[1xrs]] – CsDLAM + cobalamine + deoxyadenosine + PLP <br />
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*Glutamate-1-semialdehyde 2,1-aminomutase
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**[[2hoy]] – SeGSAM – ''Synechococcus elongatus''<br />
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**[[4e77]] – GSAM – ''Yersinia pestis''<br />
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*Glutamate-1-semialdehyde 2,1-aminomutase complexes
 
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**[[2zsl]], [[2zsm]], [[2epj]] – GSAM + PLP derivative – ''Aeropyrum pernix''<br />
 
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**[[2hp1]], [[4gsa]] – SeGSAM + PLP <br />
 
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**[[2hp2]] – SeGSAM + PLP + aminopentanoic acid derivative<br />
 
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**[[2cfb]], [[2hoz]], [[3fq7]] – SeGSAM + PLP derivative <br />
 
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**[[3fq8]] – SeGSAM (mutant) + PLP derivative <br />
 
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**[[2gsa]] – SeGSAM + PLP derivative + PLP<br />
 
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**[[2gsb]], [[3fqa]] – SeGSAM + PLP derivative + gabaculine<br />
 
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**[[2e7u]] – GSAM + PLP derivative – ''Thermus thermophilus''<br />
 
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**[[3bs8]] – GSAM (mutant) + PLP derivative – ''Bacillus subtilis''<br />
 
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**[[3l44]] – BaGSAM + PLP derivative – ''Bacillus anthracis''<br />
 
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**[[3k28]] – BaGSAM + PLP <b
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Tyrosine aminomutase complex with peptide-derived chromophore cofactor (PDB code 2ohy)

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References

  1. ↑ 1.0 1.1 Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 2007 Jun 19;46(24):7205-14. Epub 2007 May 22. PMID:17516659 doi:10.1021/bi7003685

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