Alpha-tubulin N-acetyltransferase

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<StructureSection load='3vwe' size='350' side='right' caption='Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code [[3vwe]])' scene='70/707373/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code [[3vwe]])' scene='70/707373/Cv/1'>
'''Alpha-tubulin N-acetyltransferase''' (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin.<ref>PMID:23071314</ref>
'''Alpha-tubulin N-acetyltransferase''' (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin.<ref>PMID:23071314</ref>
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<scene name='70/707373/Cv/2'>CoA binding site</scene> of α-tubulin N-acetyltransferase (PDB code [[3vwe]]).<ref>PMID:20829795</ref>
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<scene name='70/707373/Cv/3'>CoA binding site</scene> of α-tubulin N-acetyltransferase (PDB code [[3vwe]]).<ref>PMID:20829795</ref> Water molecules are shown as red spheres.
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</StructureSection>
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== 3D Structures of Alpha-tubulin N-acetyltransferase ==
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== 3D Structures of alpha-tubulin N-acetyltransferase ==
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[[Alpha-tubulin N-acetyltransferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[4gs4]], [[4b5o]], [[4if5]] – hTAT catalytic domain - human<br />
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[[4b5p]] – hTAT catalytic domain (mutant)<br />
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[[4h6z]], [[4yrh]] – zfTAT catalytic domain – zebra fish<br />
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[[4h6u]] – zfTAT catalytic domain (mutant) <br />
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[[4hkf]] – zfTAT catalytic domain + acetyl-CoA<br />
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[[3vwd]] – hTAT catalytic domain + acetoacetyl-CoA<br />
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[[3vwe]] – hTAT catalytic domain + CoA<br />
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[[4pk2]], [[4pk3]] – hTAT catalytic domain + bisubstrate analog<br />
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code 3vwe)

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References

  1. ↑ Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R. Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60. doi:, 10.1073/pnas.1209357109. Epub 2012 Oct 15. PMID:23071314 doi:10.1073/pnas.1209357109
  2. ↑ Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J. MEC-17 is an alpha-tubulin acetyltransferase. Nature. 2010 Sep 9;467(7312):218-22. doi: 10.1038/nature09324. PMID:20829795 doi:10.1038/nature09324

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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