Anthrax edema factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of | + | '''Anthrax edema factor''' (EF) or '''calmodulin-sensitive adenylate cyclase''' is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of -<BR /> |
| + | *A cell-binding protein [[Anthrax protective antigen]]<BR /> | ||
| + | *[[Anthrax Lethal Factor]]<BR /> | ||
| + | *and anthrax edema factor.<br /> | ||
| + | The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> See also [[Toxins]]. | ||
== Disease == | == Disease == | ||
| - | The anthrax disease is caused by the invasion of cells by the bacteria followed by increasing the cellular level of cAMP thus upsetting water homeostasis and causing disruption of signaling pathways. | + | The anthrax disease is caused by the invasion of cells by the bacteria followed by increasing the cellular level of cAMP thus upsetting water homeostasis and causing disruption of signaling pathways. |
| - | </ | + | |
| + | == Structural highlights == | ||
| + | |||
| + | *<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>. | ||
| + | *<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres. | ||
| + | *<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref> | ||
==3D structures of anthrax edema factor== | ==3D structures of anthrax edema factor== | ||
| + | [[Anthrax edema factor 3D structures]] | ||
| + | |||
| + | </StructureSection> | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | ||
| - | [[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | ||
| - | [[1s26]] - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP<br /> | ||
| - | [[1sk6]] - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP<br /> | ||
| - | [[1xfu]] - EF (mutant) + calmodulin<br /> | ||
| - | [[1xfv]] - EF + calmodulin + deoxy-ATP<br /> | ||
| - | [[1xfw]] - EF + calmodulin + cAMP<br /> | ||
| - | [[1xfx]], [[1xfy]], [[1xfz]] - EF + calmodulin | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Abrami L, Reig N, van der Goot FG. Anthrax toxin: the long and winding road that leads to the kill. Trends Microbiol. 2005 Feb;13(2):72-8. PMID:15680766 doi:http://dx.doi.org/10.1016/j.tim.2004.12.004
- ↑ Shen Y, Zhukovskaya NL, Zimmer MI, Soelaiman S, Bergson P, Wang CR, Gibbs CS, Tang WJ. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7. Epub 2004 Feb 20. PMID:14978283 doi:10.1073/pnas.0306552101
