4rm6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Hemopexin Binding Protein== | |
| + | <StructureSection load='4rm6' size='340' side='right'caption='[[4rm6]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4rm6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RM6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rm6 OCA], [https://pdbe.org/4rm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rm6 RCSB], [https://www.ebi.ac.uk/pdbsum/4rm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rm6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HXUA1_HAEIN HXUA1_HAEIN] Binds heme/hemopexin complexes. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Haemophilus influenzae is an obligate human commensal/pathogen that requires haem for survival and can acquire it from several host haemoproteins, including haemopexin. The haem transport system from haem-haemopexin consists of HxuC, a haem receptor, and the two-partner-secretion system HxuB/HxuA. HxuA, which is exposed at the cell surface, is strictly required for haem acquisition from haemopexin. HxuA forms complexes with haem-haemopexin, leading to haem release and its capture by HxuC. The key question is how HxuA liberates haem from haemopexin. Here, we solve crystal structures of HxuA alone, and HxuA in complex with the N-terminal domain of haemopexin. A rational basis for the release of haem from haem-haemopexin is derived from both in vivo and in vitro studies. HxuA acts as a wedge that destabilizes the two-domains structure of haemopexin with a mobile loop on HxuA that favours haem ejection by redirecting key residues in the haem-binding pocket of haemopexin. | ||
| - | + | Structural basis for haem piracy from host haemopexin by Haemophilus influenzae.,Zambolin S, Clantin B, Chami M, Hoos S, Haouz A, Villeret V, Delepelaire P Nat Commun. 2016 May 18;7:11590. doi: 10.1038/ncomms11590. PMID:27188378<ref>PMID:27188378</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Clantin | + | <div class="pdbe-citations 4rm6" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Haemophilus influenzae Rd KW20]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Clantin B]] | ||
| + | [[Category: Delepelaire P]] | ||
| + | [[Category: Haouz A]] | ||
| + | [[Category: Villeret V]] | ||
| + | [[Category: Zambolin S]] | ||
Current revision
Crystal structure of Hemopexin Binding Protein
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