1aoo

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[[Image:1aoo.gif|left|200px]]
 
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{{Structure
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==AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE==
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|PDB= 1aoo |SIZE=350|CAPTION= <scene name='initialview01'>1aoo</scene>
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<StructureSection load='1aoo' size='340' side='right'caption='[[1aoo]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=AG:SILVER+ION'>AG</scene>
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<table><tr><td colspan='2'>[[1aoo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AOO FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoo OCA], [https://pdbe.org/1aoo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aoo RCSB], [https://www.ebi.ac.uk/pdbsum/1aoo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aoo ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoo OCA], [http://www.ebi.ac.uk/pdbsum/1aoo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aoo RCSB]</span>
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<div style="background-color:#fffaf0;">
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}}
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== Publication Abstract from PubMed ==
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'''AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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==Overview==
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3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%.
3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%.
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==About this Structure==
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3D solution structure of copper and silver-substituted yeast metallothioneins.,Peterson CW, Narula SS, Armitage IM FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:8566237<ref>PMID:8566237</ref>
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1AOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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3D solution structure of copper and silver-substituted yeast metallothioneins., Peterson CW, Narula SS, Armitage IM, FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8566237 8566237]
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</div>
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<div class="pdbe-citations 1aoo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Armitage IM]]
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[[Category: Armitage, I M.]]
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[[Category: Narula SS]]
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[[Category: Narula, S S.]]
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[[Category: Peterson CW]]
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[[Category: Peterson, C W.]]
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[[Category: copper detoxification]]
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[[Category: metal-thiolate cluster]]
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[[Category: metallothionein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:33 2008''
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AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1aoo

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