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4ya8

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==structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394==
==structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394==
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<StructureSection load='4ya8' size='340' side='right' caption='[[4ya8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='4ya8' size='340' side='right'caption='[[4ya8]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ya8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YA8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ya8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YA8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49W:N-[(2S,3S)-3-HYDROXY-1-PHENYL-4-{[2-(PYRIDIN-2-YL)PROPAN-2-YL]AMINO}BUTAN-2-YL]-N,N-DIPROPYL-5-(PYRIDIN-1(2H)-YL)BENZENE-1,3-DICARBOXAMIDE'>49W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.301&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49W:N-[(2S,3S)-3-HYDROXY-1-PHENYL-4-{[2-(PYRIDIN-2-YL)PROPAN-2-YL]AMINO}BUTAN-2-YL]-N,N-DIPROPYL-5-(PYRIDIN-1(2H)-YL)BENZENE-1,3-DICARBOXAMIDE'>49W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ya8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ya8 OCA], [http://pdbe.org/4ya8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ya8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ya8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ya8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ya8 OCA], [https://pdbe.org/4ya8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ya8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ya8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ya8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:8844673, PubMed:11782538, PubMed:15574427). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ya8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ya8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Plasmepsin|Plasmepsin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plasmepsin II]]
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[[Category: Large Structures]]
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[[Category: Jaudzems, K]]
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[[Category: Plasmodium falciparum]]
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[[Category: Leitans, J]]
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[[Category: Jaudzems K]]
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[[Category: Recacha, R]]
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[[Category: Leitans J]]
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[[Category: Tars, K]]
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[[Category: Recacha R]]
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[[Category: Hydrolase]]
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[[Category: Tars K]]
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[[Category: Inhibitor]]
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[[Category: Malaria]]
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[[Category: Plasmepsin ii]]
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Current revision

structure of plasmepsin II from Plasmodium Falciparum complexed with inhibitor PG394

PDB ID 4ya8

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