Choline kinase

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== Structural highlights ==
== Structural highlights ==
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The choline binds to CK in a <scene name='59/593958/Cv/2'>deep hydrophobic groove</scene> (PDB code [[2ckq]]) and the ADP binds in a cleft (PDB code [[2ckp]]). <ref>PMID:17007874</ref>
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The choline binds to CK in a <scene name='59/593958/Cv/5'>deep hydrophobic groove</scene> (PDB code [[2ckq]]; {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}) and the <scene name='59/593958/Cv/6'>ADP binds in a cleft</scene> (PDB code [[2ckp]]). <ref>PMID:17007874</ref>
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</StructureSection>
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==3D structures of choline kinase==
==3D structures of choline kinase==
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[[Choline kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Choline kinase
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**[[2i7q]] – hCK α – human<br />
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**[[2cko]] – hCK α2 <br />
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**[[2ig7]] – hCK β <br />
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**[[1nw1]] – CK – ''Caenorhabditis elegans'' <br />
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**[[3c5i]] – CK – ''Plasmodium knowlesi''<br />
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**[[3fi8]] – CK – ''Plasmodium falciparum''<br />
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**[[3mes]] – CK – ''Cryptosporidium pavrum''<br />
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*Choline kinase complexes
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**[[2ckp]] – hCK α2 + ADP<br />
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**[[2ckq]] – hCK α2 + phosphocholine<br />
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**[[3zm9]], [[4da5]], [[4br3]] – hCK α + inhibitor<br />
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**[[3f2r]] – hCK α + hemicholinium-3<br />
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**[[3g15]] – hCK α + hemicholinium-3 + ADP<br />
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**[[3lq3]], [[3feg]] – hCK β + hemicholinium-3 + ADP<br />
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**[[4cg8]], [[4cg9]], [[4cga]] – hCK α1 + bispyridinium derivative<br />
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}}
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== References ==
== References ==

Current revision

Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckq).

Drag the structure with the mouse to rotate

References

  1. ↑ Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3. PMID:17007874 doi:10.1016/j.jmb.2006.08.084

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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