1ass

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[[Image:1ass.gif|left|200px]]
 
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{{Structure
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==APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM==
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|PDB= 1ass |SIZE=350|CAPTION= <scene name='initialview01'>1ass</scene>, resolution 2.3&Aring;
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<StructureSection load='1ass' size='340' side='right'caption='[[1ass]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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<table><tr><td colspan='2'>[[1ass]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ASS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= THSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ass FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ass OCA], [https://pdbe.org/1ass PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ass RCSB], [https://www.ebi.ac.uk/pdbsum/1ass PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ass ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ass FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ass OCA], [http://www.ebi.ac.uk/pdbsum/1ass PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ass RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/THSA_THEAC THSA_THEAC] Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/1ass_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ass ConSurf].
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<div style="clear:both"></div>
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'''APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM'''
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==See Also==
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*[[Chaperonin 3D structures|Chaperonin 3D structures]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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==Overview==
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__TOC__
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The crystal structure of the substrate binding domain of the thermosome, the archaeal group II chaperonin, has been determined at 2.3 A resolution. The core resembles the apical domain of GroEL but lacks the hydrophobic residues implied in binding of substrates to group I chaperonins. Rather, a large hydrophobic surface patch is found in a novel helix-turn-helix motif, which is characteristic of all group II chaperonins including the eukaryotic TRiC/CCT complex. Models of the holochaperonin, which are consistent with cryo electron microscopy data, suggest a dual role of this helical protrusion in substrate binding and controlling access to the central cavity independent of a GroES-like cochaperonin.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1ASS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASS OCA].
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==Reference==
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Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin., Klumpp M, Baumeister W, Essen LO, Cell. 1997 Oct 17;91(2):263-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9346243 9346243]
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[[Category: Single protein]]
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[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: Baumeister, W.]]
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[[Category: Baumeister W]]
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[[Category: Essen, L O.]]
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[[Category: Essen L-O]]
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[[Category: Klumpp, M.]]
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[[Category: Klumpp M]]
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[[Category: atp-binding]]
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[[Category: chaperonin]]
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[[Category: groel]]
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[[Category: hsp60]]
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[[Category: tcp1]]
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[[Category: thermoplasma acidophilum]]
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[[Category: thermosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:46:49 2008''
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Current revision

APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM

PDB ID 1ass

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