4zqo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:20, 3 January 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67==
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67==
-
<StructureSection load='4zqo' size='340' side='right' caption='[[4zqo]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
+
<StructureSection load='4zqo' size='340' side='right'caption='[[4zqo]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQO FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQO FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=Q67:N~2~-(2,3-DICHLOROPHENYL)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]-L-ALANINAMIDE'>Q67</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqn|4zqn]], [[4zqm|4zqm]], [[4zqp|4zqp]], [[4zqr|4zqr]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=Q67:N~2~-(2,3-DICHLOROPHENYL)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]-L-ALANINAMIDE'>Q67</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqo OCA], [http://pdbe.org/4zqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqo RCSB], [http://www.ebi.ac.uk/pdbsum/4zqo PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqo OCA], [https://pdbe.org/4zqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqo RCSB], [https://www.ebi.ac.uk/pdbsum/4zqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
+
[https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 4zqo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zqo" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Andesrson, W F]]
+
[[Category: Large Structures]]
-
[[Category: Structural genomic]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Gu, M]]
+
[[Category: Anderson WF]]
-
[[Category: Hedstrom, L]]
+
[[Category: Gu M]]
-
[[Category: Joachimiak, A]]
+
[[Category: Hedstrom L]]
-
[[Category: Kavitha, M]]
+
[[Category: Joachimiak A]]
-
[[Category: Kim, Y]]
+
[[Category: Kavitha M]]
-
[[Category: Makowska-Grzyska, M]]
+
[[Category: Kim Y]]
-
[[Category: Csgid]]
+
[[Category: Makowska-Grzyska M]]
-
[[Category: Delta cb]]
+
-
[[Category: Impdh]]
+
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+

Current revision

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67

PDB ID 4zqo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zqo"
Personal tools