5aoh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of CarF== | |
| + | <StructureSection load='5aoh' size='340' side='right'caption='[[5aoh]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5aoh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_sp._ATCC_39006 Serratia sp. ATCC 39006]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AOH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aoh OCA], [https://pdbe.org/5aoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aoh RCSB], [https://www.ebi.ac.uk/pdbsum/5aoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aoh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A2I5TIN5_SERS3 A0A2I5TIN5_SERS3] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The natural production of the beta-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived. | ||
| - | + | 1.8 A resolution crystal structure of the carbapenem intrinsic resistance protein CarF.,Tichy EM, Hardwick SW, Luisi BF, Salmond GPC Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):549-556. doi:, 10.1107/S2059798317002236. Epub 2017 Jun 22. PMID:28695855<ref>PMID:28695855</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5aoh" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Hardwick | + | <references/> |
| - | [[Category: Tichy | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Serratia sp. ATCC 39006]] | ||
| + | [[Category: C Salmond GP]] | ||
| + | [[Category: Hardwick SW]] | ||
| + | [[Category: Luisi BF]] | ||
| + | [[Category: Tichy EM]] | ||
Current revision
Crystal Structure of CarF
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