5b0o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the FliH-FliI complex== | |
| + | <StructureSection load='5b0o' size='340' side='right'caption='[[5b0o]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5b0o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B0O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b0o OCA], [https://pdbe.org/5b0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b0o RCSB], [https://www.ebi.ac.uk/pdbsum/5b0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b0o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FLII_SALTY FLII_SALTY] Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | FliI and FliJ form the FliI6FliJ ATPase complex of the bacterial flagellar export apparatus, a member of the type III secretion system. The FliI6FliJ complex is structurally similar to the alpha3beta3gamma complex of F1-ATPase. The FliH homodimer binds to FliI to connect the ATPase complex to the flagellar base, but the details are unknown. Here we report the structure of the homodimer of a C-terminal fragment of FliH (FliHC2) in complex with FliI. FliHC2shows an unusually asymmetric homodimeric structure that markedly resembles the peripheral stalk of the A/V-type ATPases. The FliHC2-FliI hexamer model reveals that the C-terminal domains of the FliI ATPase face the cell membrane in a way similar to the F/A/V-type ATPases. We discuss the mechanism of flagellar ATPase complex formation and a common origin shared by the type III secretion system and the F/A/V-type ATPases. | ||
| - | + | Insight into the flagella type III export revealed by the complex structure of the type III ATPase and its regulator.,Imada K, Minamino T, Uchida Y, Kinoshita M, Namba K Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3633-8. doi:, 10.1073/pnas.1524025113. Epub 2016 Mar 16. PMID:26984495<ref>PMID:26984495</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Imada | + | <div class="pdbe-citations 5b0o" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Minamino | + | ==See Also== |
| - | [[Category: Namba | + | *[[Flagellar protein 3D structures|Flagellar protein 3D structures]] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]] | ||
| + | [[Category: Imada K]] | ||
| + | [[Category: Kinoshita M]] | ||
| + | [[Category: Minamino T]] | ||
| + | [[Category: Namba K]] | ||
| + | [[Category: Uchida Y]] | ||
Current revision
Structure of the FliH-FliI complex
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