5cv3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==C. remanei PGL-1 Dimerization Domain - Hg== | |
| - | + | <StructureSection load='5cv3' size='340' side='right'caption='[[5cv3]], [[Resolution|resolution]] 3.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_remanei Caenorhabditis remanei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CV3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1701477Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cv3 OCA], [https://pdbe.org/5cv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cv3 RCSB], [https://www.ebi.ac.uk/pdbsum/5cv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cv3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Kimble | + | [https://www.uniprot.org/uniprot/PGL1_CAERE PGL1_CAERE] Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate (PubMed:26787882). Essential role in male and female postembryonic germline development; maternally provided protein maintains a population of proliferating germ cells and zygotic expression is required for correct oogenesis (By similarity). Together with the P-granule component pgl-3, is involved in the formation of P-granules (By similarity). Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules (By similarity). In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis during normal oogenesis and development of the two gonadal arms (By similarity). This may in part be through regulating the localization of sir-2.1 which is involved in germ cell apoptosis (By similarity). May protect somatic cells from excessive apoptosis during normal development (By similarity).[UniProtKB:Q9TZQ3]<ref>PMID:26787882</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis remanei]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aoki ST]] | ||
| + | [[Category: Bingman CA]] | ||
| + | [[Category: Kimble JE]] | ||
| + | [[Category: Wickens M]] | ||
Current revision
C. remanei PGL-1 Dimerization Domain - Hg
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