5d14
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The atomic resolution crystal structure of human IL-8== |
| + | <StructureSection load='5d14' size='340' side='right'caption='[[5d14]], [[Resolution|resolution]] 1.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5d14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D14 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d14 OCA], [https://pdbe.org/5d14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d14 RCSB], [https://www.ebi.ac.uk/pdbsum/5d14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d14 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Brzezinski | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Lu | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Brzezinski K]] |
| + | [[Category: Jakoncic J]] | ||
| + | [[Category: Lu S]] | ||
| + | [[Category: Ostrov DA]] | ||
| + | [[Category: Pompeu Y]] | ||
Current revision
The atomic resolution crystal structure of human IL-8
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