5d8f

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'''Unreleased structure'''
 
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The entry 5d8f is ON HOLD until Paper Publication
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==crystal structure of SSB and ssDNA complex from homo sapiens==
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<StructureSection load='5d8f' size='340' side='right'caption='[[5d8f]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5d8f]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D8F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8f OCA], [https://pdbe.org/5d8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d8f RCSB], [https://www.ebi.ac.uk/pdbsum/5d8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
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Authors: Li, Y.H., Gao, Z.Q., Dong, Y.H.
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==See Also==
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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Description: crystal structure of SSB and ssDNA complex from homo sapiens
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Gao, Z.Q]]
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__TOC__
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[[Category: Dong, Y.H]]
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</StructureSection>
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[[Category: Li, Y.H]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Dong YH]]
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[[Category: Gao ZQ]]
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[[Category: Li YH]]

Current revision

crystal structure of SSB and ssDNA complex from homo sapiens

PDB ID 5d8f

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