5dur

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==Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4==
==Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4==
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<StructureSection load='5dur' size='340' side='right' caption='[[5dur]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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<StructureSection load='5dur' size='340' side='right'caption='[[5dur]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DUR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5dur]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Anhui/1/2005(H5N1)) Influenza A virus (A/Anhui/1/2005(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DUR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dum|5dum]], [[5dup|5dup]], [[5dut|5dut]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [http://pdbe.org/5dur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [http://www.ebi.ac.uk/pdbsum/5dur PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dur OCA], [https://pdbe.org/5dur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dur RCSB], [https://www.ebi.ac.uk/pdbsum/5dur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dur ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
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[https://www.uniprot.org/uniprot/Q1WDM0_9INFA Q1WDM0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dur" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dur" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sun, J]]
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[[Category: Homo sapiens]]
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[[Category: Wang, G]]
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[[Category: Large Structures]]
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[[Category: Wang, X]]
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[[Category: Sun J]]
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[[Category: Zhang, L]]
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[[Category: Wang G]]
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[[Category: Zhou, P]]
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[[Category: Wang X]]
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[[Category: Zuo, T]]
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[[Category: Zhang L]]
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[[Category: Antibody]]
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[[Category: Zhou P]]
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[[Category: Complex]]
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[[Category: Zuo T]]
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[[Category: Immune system]]
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[[Category: Influenza virus]]
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[[Category: Neutralize]]
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Current revision

Influenza A virus H5 hemagglutinin globular head in complex with antibody 100F4

PDB ID 5dur

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