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5a9f

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==Crystal structure of the Helicase domain of human DNA polymerase theta in complex with ADP==
==Crystal structure of the Helicase domain of human DNA polymerase theta in complex with ADP==
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<StructureSection load='5a9f' size='340' side='right' caption='[[5a9f]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='5a9f' size='340' side='right'caption='[[5a9f]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5a9f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A9F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5a9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A9F FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a9j|5a9j]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9f OCA], [https://pdbe.org/5a9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a9f RCSB], [https://www.ebi.ac.uk/pdbsum/5a9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9f ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9f OCA], [http://pdbe.org/5a9f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a9f RCSB], [http://www.ebi.ac.uk/pdbsum/5a9f PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>
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[https://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5a9f" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a9f" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Homo sapiens]]
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[[Category: Aitkenhead, H]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Aitkenhead H]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess-Brown, N]]
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[[Category: Bountra C]]
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[[Category: Cooper, C D.O]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von]]
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[[Category: Cooper CDO]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi O]]
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[[Category: Kupinska, K]]
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[[Category: Kupinska K]]
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[[Category: Newman, J A]]
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[[Category: Newman JA]]
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[[Category: Pinkas, D M]]
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[[Category: Pinkas DM]]
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[[Category: Dna repair]]
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[[Category: Von Delft F]]
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[[Category: Helicase]]
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[[Category: Polq]]
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[[Category: Polymerase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Helicase domain of human DNA polymerase theta in complex with ADP

PDB ID 5a9f

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