This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1b1z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:55, 3 April 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1b1z.gif|left|200px]]
 
-
{{Structure
+
==STREPTOCOCCAL PYROGENIC EXOTOXIN A1==
-
|PDB= 1b1z |SIZE=350|CAPTION= <scene name='initialview01'>1b1z</scene>, resolution 2.57&Aring;
+
<StructureSection load='1b1z' size='340' side='right'caption='[[1b1z]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1b1z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B1Z FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b1z OCA], [https://pdbe.org/1b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b1z RCSB], [https://www.ebi.ac.uk/pdbsum/1b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b1z ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b1z OCA], [http://www.ebi.ac.uk/pdbsum/1b1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1b1z RCSB]</span>
+
[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/1b1z_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b1z ConSurf].
 +
<div style="clear:both"></div>
-
'''STREPTOCOCCAL PYROGENIC EXOTOXIN A1'''
+
==See Also==
-
 
+
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
Streptococcal pyrogenic exotoxin A (SpeA) is a superantigen produced by Streptococcus pyogenes and is associated with severe infections characterized by rash, hypotension, multiorgan failure and a high mortality rate. In this study, an allelic form of this toxin, SpeA1, was crystallized with four molecules in the crystallographic asymmetric unit and its crystal structure was determined at 2.6 A resolution. The crystallographic R-factor was 19.4% (33 497 reflections) for 7031 protein atoms and 88 water molecules. The overall structure of SpeA1 is considerably similar to that of other prototype microbial superantigens, either of staphylococcal or streptococcal origin, but has greatest similarity to staphylococcal enterotoxin C (SEC). Based on structural and mutagenesis data, we have mapped several important residues on the toxin molecule, which are involved in the recognition of major histocompatibility complex (MHC) class II molecules and T-cell receptors. Also, the toxin appears to possess a potential zinc-binding site which may have implications in binding to particular MHC class II molecules. Finally, we propose models for SpeA1-MHC class II and SpeA1-T-cell receptor association and the relevance of this phenomenon to the superantigenic action of this toxin is considered.
+
[[Category: Large Structures]]
-
 
+
-
==About this Structure==
+
-
1B1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B1Z OCA].
+
-
 
+
-
==Reference==
+
-
Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors., Papageorgiou AC, Collins CM, Gutman DM, Kline JB, O'Brien SM, Tranter HS, Acharya KR, EMBO J. 1999 Jan 4;18(1):9-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9878045 9878045]
+
-
[[Category: Single protein]]
+
[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
-
[[Category: Acharya, K R.]]
+
[[Category: Acharya KR]]
-
[[Category: Papageorgiou, A C.]]
+
[[Category: Papageorgiou AC]]
-
[[Category: pyrogenic exotoxin]]
+
-
[[Category: superantigen]]
+
-
[[Category: zinc binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:51:53 2008''
+

Current revision

STREPTOCOCCAL PYROGENIC EXOTOXIN A1

PDB ID 1b1z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b1z"
Personal tools