4s0h

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==TBX5 DB, NKX2.5 HD, ANF DNA Complex==
==TBX5 DB, NKX2.5 HD, ANF DNA Complex==
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<StructureSection load='4s0h' size='340' side='right' caption='[[4s0h]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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<StructureSection load='4s0h' size='340' side='right'caption='[[4s0h]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4s0h]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4s0h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0H FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0h OCA], [http://pdbe.org/4s0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0h RCSB], [http://www.ebi.ac.uk/pdbsum/4s0h PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.817&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0h OCA], [https://pdbe.org/4s0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0h RCSB], [https://www.ebi.ac.uk/pdbsum/4s0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0h ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN]] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry. Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> [[http://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN]] Athyreosis;Familial isolated congenital asplenia;Atrial septal defect - atrioventricular conduction defects;Atrial septal defect, ostium secundum type;Hypoplastic left heart syndrome;Tetralogy of Fallot;Familial atrial fibrillation;Familial progressive cardiac conduction defect;Thyroid hypoplasia;Ventricular septal defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry. Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN]] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref> [[http://www.uniprot.org/uniprot/NKX25_HUMAN NKX25_HUMAN]] Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development.<ref>PMID:22560297</ref>
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[https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref>
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==See Also==
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*[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]]
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*[[T-box proteins|T-box proteins]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pradhan, L]]
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[[Category: Homo sapiens]]
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[[Category: Transcription factor]]
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[[Category: Large Structures]]
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[[Category: Transcription-dna complex]]
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[[Category: Synthetic construct]]
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[[Category: Pradhan L]]

Current revision

TBX5 DB, NKX2.5 HD, ANF DNA Complex

PDB ID 4s0h

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