2n9v
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n9v is ON HOLD Authors: Hisao, G.S., Brothers, M.C., Ho, M., Wilson, B.A., Rienstra, C.M. Description: Solution NMR Structure of the membrane loca...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR Structure of the membrane localization domain from Pasteurella multocida toxin== | |
| + | <StructureSection load='2n9v' size='340' side='right'caption='[[2n9v]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_multocida Pasteurella multocida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9V FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9v OCA], [https://pdbe.org/2n9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9v RCSB], [https://www.ebi.ac.uk/pdbsum/2n9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TOXA_PASMD TOXA_PASMD] This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Membrane localization domain (MLD) was first proposed for a 4-helix-bundle motif in the crystal structure of the C1 domain of Pasteurella multocida toxin (PMT). This structure motif is also found in the crystal structures of several clostridial glycosylating toxins (TcdA, TcdB, TcsL, and TcnA). The Ras/Rap1-specific endopeptidase (RRSP) module of the multifunctional autoprocessing repeats-in-toxins (MARTX) toxin produced by Vibrio vulnificus has sequence homology to the C1-C2 domains of PMT, including a putative MLD. We have determined the solution structure for the MLDs in PMT and in RRSP using solution state NMR. We conclude that the MLDs in these two toxins assume a 4-helix-bundle structure in solution. This article is protected by copyright. All rights reserved. | ||
| - | + | The membrane localization domains of two distinct bacterial toxins form a 4-helix-bundle in solution.,Hisao GS, Brothers MC, Ho M, Wilson BA, Rienstra CM Protein Sci. 2016 Dec 15. doi: 10.1002/pro.3097. PMID:27977897<ref>PMID:27977897</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n9v" style="background-color:#fffaf0;"></div> |
| - | [[Category: Hisao | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Wilson | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pasteurella multocida]] | ||
| + | [[Category: Brothers MC]] | ||
| + | [[Category: Hisao GS]] | ||
| + | [[Category: Ho M]] | ||
| + | [[Category: Rienstra CM]] | ||
| + | [[Category: Wilson BA]] | ||
Current revision
Solution NMR Structure of the membrane localization domain from Pasteurella multocida toxin
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