5fai

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m (Protected "5fai" [edit=sysop:move=sysop])
Current revision (06:44, 19 July 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5fai is ON HOLD
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==EMG1 N1-Specific Pseudouridine Methyltransferase==
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<StructureSection load='5fai' size='340' side='right'caption='[[5fai]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: DONG, A., ZENG, H., LI, Y., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FAI FirstGlance]. <br>
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Description: EMG1 N1-Specific Pseudouridine Methyltransferase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Dong, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fai OCA], [https://pdbe.org/5fai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fai RCSB], [https://www.ebi.ac.uk/pdbsum/5fai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fai ProSAT]</span></td></tr>
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[[Category: Li, Y]]
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</table>
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[[Category: Zeng, H]]
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== Disease ==
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[[Category: Wu, H]]
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[https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] Bowen-Conradi syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Bountra, C]]
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== Function ==
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[[Category: Tempel, W]]
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[https://www.uniprot.org/uniprot/NEP1_HUMAN NEP1_HUMAN] S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity).[UniProtKB:Q06287]<ref>PMID:20047967</ref>
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[[Category: Arrowsmith, C.H]]
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== References ==
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[[Category: Brown, P.J]]
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<references/>
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[[Category: Edwards, A.M]]
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__TOC__
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[[Category: Structural Genomics Consortium (Sgc)]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: BROWN PJ]]
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[[Category: Bountra C]]
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[[Category: DONG A]]
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[[Category: Edwards AM]]
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[[Category: LI Y]]
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[[Category: TEMPEL W]]
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[[Category: WU H]]
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[[Category: ZENG H]]

Current revision

EMG1 N1-Specific Pseudouridine Methyltransferase

PDB ID 5fai

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