5fbr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PI4KB in complex with Rab11 and the MI359 Inhibitor== | |
| + | <StructureSection load='5fbr' size='340' side='right'caption='[[5fbr]], [[Resolution|resolution]] 3.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fbr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.28Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5W7:~{N}-[2-[[3-[3-[(4-AZANYLCYCLOHEXYL)SULFAMOYL]-4-METHOXY-PHENYL]-6-CHLORANYL-2-METHYL-IMIDAZO[1,2-B]PYRIDAZIN-8-YL]AMINO]ETHYL]ETHANAMIDE'>5W7</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbr OCA], [https://pdbe.org/5fbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbr RCSB], [https://www.ebi.ac.uk/pdbsum/5fbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]] | |
| - | + | *[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Boura | + | <references/> |
| - | [[Category: Chalupska | + | __TOC__ |
| - | [[Category: Mejdrova | + | </StructureSection> |
| - | [[Category: Nencka | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Boura E]] | ||
| + | [[Category: Chalupska D]] | ||
| + | [[Category: Mejdrova I]] | ||
| + | [[Category: Nencka R]] | ||
Current revision
PI4KB in complex with Rab11 and the MI359 Inhibitor
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